Program

Thank you for your interest in the AMP 2017 Annual Meeting! The program is being developed by the AMP 2017 Annual Meeting Program Committee and should be final by mid-June. Check back often for updates.

Tuesday, November 14, 2017

GENERAL INFORMATION

8:00am - 5:00pm

AMP Reference Materials Forum (Separate Registration)

10:30am - 11:15am

Executive Committee Meeting (Invitation Only)

11:30am - 6:00pm

Board of Directors Meeting (Invitation Only)

2:00pm - 6:00pm

Attendee, Speaker and Exhibitor Registration and Check-In

6:30pm

Board of Directors Dinner (Invitation Only)

 

Wednesday, November 15, 2017

GENERAL INFORMATION

7:00am - 5:00pm

Attendee, Speaker, and Exhibitor Registration and Check-In

7:30am - 5:00pm

AMP Committee Meetings (Invitation Only)

8:00am - 5:00pm

Corporate Workshop Day (No Registration Required!)

8:30am - 3:45pm

Molecular Pathology Outreach Course (MPOC)

(Separate Registration)

 

Thursday, November 16, 2017

GENERAL INFORMATION

6:30am - 8:00am

Poster Set-Up

6:45am - 5:00pm

Attendee, Speaker, and Exhibitor Registration and Check-In

7:00am - 8:00am

Continental Breakfast

11:30am - 4:30pm

Exhibit Hall Open

5:45pm - 7:00pm

Welcome Reception (In the Exhibit Hall)

SCIENTIFIC INFORMATION

7:00am - 8:00am

EARLY BIRD SESSIONS

Standardization of Projects in Pharmacogenetics

AMP CYP2C19 PGx Variant Standardization Project
Victoria M. Pratt, PhD, FACMG, Indiana University, Indianapolis, IN, USA

PGx  Standardization Project
Steven A. Schichmann, MD, PhD, John L. McClellan Memorial Veterans Hospital, Little Rock, AR, USA

The Utah Genome Project

Utah Genome Project: Genetic Discovery Powered by Utah's Large Families and Population Database
Deborah Neklason, PhD, University of Utah, Salt Lake City, UT, USA

Molecular Diagnostics for Biomarker-Driven Clinical Trials

The Challenges of Development and Application of the NCI-MATCH NGS Assay

P. Mickey Williams, PhD, Frederick National Labs, Frederick, MD, USA

Pediatric Clinical Trial Networks, Pathologist's Perspective
Marian H. Harris, MD, PhD, Boston Children's Hospital, Boston, MA, USA

Applications of Multiplex Molecular Imaging in Cancer

High Dimensional Imaging of Tumor Immune Infiltrates Using MIBI
Michael Angelo, MD, PhD, Stanford University, Palo Alto, CA, USA

8:00am - 8:15am

Break

8:15am - 8:30am

Opening Remarks

Daniel E. Sabath MD, PhD
University of Washington, Seattle, WA, USA
2017 Program Chair

8:30am - 9:45am

AMP Award for Excellence in Molecular Diagnostics: Presentation and Lecture

The Epigenetic Basis of Common Human Disease
Andrew P. Feinberg, MD, MPH, Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA

9:45am -10:15am

Coffee Break

10:15am - 11:45am

CANCER/ONCOLOGY PLENARY SESSION

Molecular Genetics and Biomarkers of B-cell Leukemias and Lymphomas

Precursor B-cell Neoplasms (ALL)
Charles G. Mullighan, MBBS (Hons), MSc, MD, St. Jude Children's Research Hospital, Memphis, TN, USA

Genetic Basis of Diffuse Large B-cell Lymphoma
Laura Pasqualucci, MD, Columbia University Medical Center, New York, NY, USA

11:45am - 1:00pm

General Lunch - Visit Exhibit Hall and View Posters

Networking Lunches (schedule)

1:00pm - 2:30pm

CONCURRENT WORKSHOPS

MRD Assessment in Acute Leukemias

Deep NGS for AML/MDS MRD
David H. Spencer, MD, PhD, Washington University School of Medicine, St. Louis, MO, USA

T-cell or B-cell Receptor NGS for MRD

David Wu, MD, PhD, University of Washington, Seattle, WA, USA

Discovering the Links: Infectious Agents and Cancer

HPV and Head and Neck Cancer
Joseph A. Califano, MD, University of California, San Diego, CA, USA

Blood-based Assessment of EBV DNA as a Tumor Marker
Jennifer A. Kanakry, MD, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Pharmacogenomics Implementation

Clinical Implementation of Pharmacogenomics: From Reactive Testing to Preemptive Testing
Ann M. Moyer, MD, PhD, Mayo Clinic, Rochester, MN, USA

Implementing and Assessing Outcomes with Genotype-Guided Therapy
Larisa H. Cavallari, PharmD, University of Florida, College of Pharmacy, Gainesville, FL, USA

Bioinformatic Frontiers: Dissecting the Genetics of Cancer

Computational Dissection of Intra-tumor Genetic Heterogeneity and Applications to the Study of Cancer Treatment, Evolution, and Metastasis

Scott L. Carter, PhD, Dana-Farber Cancer Institute, Boston, MA, USA

Strategies and Challenges for Somatic Mutation Detection by Next-gen Sequencing
Daniel C. Koboldt, MSc, Institute for Genomic Medicine at Nationwide Children's Hospital, Columbus, OH, USA

Genetics of Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis: A Timely Review

Perspectives and Diagnostic Considerations in Spinal Muscular Atrophy
Thomas W. Prior, PhD, Ohio State University, Columbus, OH, USA

Genetics of ALS
Vivianna M. Van Deerlin, MD, PhD, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA

 

2:30pm - 4:15pm

Coffee Break - Visit Exhibit Hall and View Posters

4:15pm - 5:45pm

INFECTIOUS DISEASES PLENARY SESSION

The Hunt for Microbes: The Beginning of the End of the Pandemic Era

Microbial Anthropology
Maria G. Dominguez-Bello, PhD, BSc, MSc, New York University School of Medicine, New York, NY, USA

A Collaborative Effort to End the Pandemic Era: The Global Virome Project
Jonna Mazet, DVM, MPVM, PhD, One Health Institute, University of California, Davis, CA,USA

5:45pm - 7:00pm

Welcome Reception (In the Exhibit Hall)

7:30pm - 9:00pm

JMD Editorial Board Dinner (Invitation Only)

 

Friday, November 17, 2017

GENERAL INFORMATION

6:45am - 5:00pm

Attendee, Speaker, and Exhibitor Registration and Check-In

7:00am - 8:00am

Continental Breakfast

9:00am - 4:00pm

Exhibit Hall Open

SCIENTIFIC INFORMATION

7:00am - 8:00am

EARLY BIRD SESSIONS

Novel Technologies:
Cool Toys for You Now and in the Future

Gene Expression Profiling During Infection Using Digital Barcoded Probe Technology
Aaron P. Mitchell, PhD, Carnegie Mellon University, Pittsburgh, PA, USA

Implementation of a Diagnostic Device Syndromic Disease Network
Lindsay Meyers, BSc, BioFire Diagnostics, LLC, Salt Lake City, Utah, USA

Introduction to Smarticles™ Technology: Potential Applications in Antimicrobial Stewardship
Michael Lewinski, PhD, D(ABMM), Roche Molecular Systems, Inc., Pleasanton, CA, USA

Data Visualization

Enabling Scientific Discovery Through Interactive Visual Data Analysis
Alexander Lex, PhD, University of Utah, Salt Lake City, UT, USA

New Tools for Detecting Low Frequency Variants Applications in Hematopoietic Neoplasms

Single Molecule Quantification of Rare DNA and RNA Variants in Heterogeneous Samples
Todd E. Druley, MD, PhD, Washington University School of Medicine, St. Louis, MO, USA

Coding (and Other) Conundrums
(Sponsored by the Economic Affairs Committee)

Panel Discussion
Aaron D. Bossler, MD, PhD, University of Iowa, Iowa City, IA, USA
(EAC Vice-Chair New Codes Subcommittee)
 
Richard D. Press, MD, PhD, Oregon Health & Sciences University, Portland, OR, USA
(EAC Vice-Chair Coverage Subcommittee)
 

Anthony N. Sireci, MD, Columbia University Medical Center, New York, NY, USA  
(EAC Vice-Chair Pricing Subcommittee)

 

8:00am - 9:00am

SPECIAL SESSION: INFECTIOUS DISEASES

Molecular Infectious Disease Testing: Point of Care Challenges

Molecular Point-of-Care Tests for Infectious Diseases: Opportunities and Challenges
Frederick S. Nolte, PhD, D(ABMM), F(AAM), Medical University of South Carolina, Charleston, SC, USA

8:00am - 8:15am

Break

8:15am - 9:45am

PLENARY SESSION

Molecular Informatics at Scale for Genomics-based Personalized Cancer Care

Molecular Pathology Informatics - Toolsets and Infrastructures for Supporting Clinical Trials
Mark Routbort, MD, PhD, University of Texas MD Anderson Cancer Center, Houston, TX, USA

Interpreting the Cancer Genome: Identifying Driver Alterations and Therapeutic Options
Nikolaus Schultz, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, USA

9:45am - 10:45am

Coffee Break - Visit Exhibit Hall and View Posters

10:45am - 11:45am

CONCURRENT WORKSHOPS:

Platform Presentations of Selected Abstracts

Abstracts are selected by the Program Committee

Genetics Platform Presentation

HemePath Platform Presentation

Infectious Diseases Platform Presentation

Informatics Platform Presentation

Solid Tumors Platform Presentation

11:45am - 1:00pm

General Lunch - Visit Exhibit Hall and View Posters

Networking Lunches (schedule)

1:00pm - 2:30pm

CANCER/ONCOLOGY PLENARY SESSION

High Impact Molecular Diagnostics for Cancer and Inherited Diseases

Clinical Utility of Lung Cancer Genotyping
A. John Iafrate, MD, PhD, Massachusetts General Hospital, Boston, MA, USA

Detection and Interpretation of Germline Variants in Cancer Patients (with an Emphasis on Demonstrating the Clinical Utility and Impact of the Molecular Pathologist)
Colin C. Pritchard, MD, PhD, University of Washington, Seattle, WA, USA

SPECIAL SESSION: INFECTIOUS DISEASES

Unmet Needs in Infectious Disease Diagnostics

Panel Discussion
Gregory A. Storch, MD, Washington University School of Medicine, St. Louis, MO, USA

Kimberly Hanson, MD, MHS, University of Utah, Salt Lake City, UT, USA

2:30pm - 3:30pm

Coffee Break - Visit Exhibit Hall and View Posters

3:30pm - 5:00pm

CONCURRENT SYMPOSIA

Genome Evolution and Therapy Resistance in Lymphoid and Myeloid Neoplasms

Correlation of AML and MDS Mutation Burdens and Response to Decitabine in the Peripheral Blood and Bone Marrow
John S. Welch, MD, PhD, Washington University School of Medicine, St. Louis, MO, USA

Dynamic Monitoring of Lymphoma Genome Evolution
Ash A. Alizadeh, MD, PhD, Stanford University School of Medicine, Stanford, CA, USA

Molecular Testing in the Practice of Cardiology

Phenotype to Genotype: How Traditional Techniques Pave the Way to Targeted Testing and Individualized Medicine
Joseph J. Maleszewski, MD, Mayo Clinic, Rochester, MN, USA

From Genes to Genomes - Evolution of Molecular Testing for Inherited Cardiomyopathies

Birgit Funke, PhD, Veritas Genetics, Danvers, MA, USA
Harvard Medical School, Boston, MA, USA

4:15pm - 5:00pm

SPECIAL SESSION: INFECTIOUS DISEASES

ID Town Hall Meeting

5:00pm - 5:15pm

Break

5:15pm - 6:30pm

Business Meeting and Awards Session

(Open to All Registered Attendees)

7:00pm - 10:30pm

AMP 2017 Social Event

 

 

Saturday, November 18, 2017

GENERAL INFORMATION

7:00am - 5:00pm

Attendee, Speaker, and Exhibitor Registration and Check-In

7:00am - 8:00am

Continental Breakfast

9:00am - 1:30pm

Exhibit Hall Open

SCIENTIFIC INFORMATION

7:00am - 8:00am

EARLY BIRD SESSIONS

Biorepositories in Precision Medicine

The Role of Biobanks in Precision Medicine Research and Care
Nazneen Aziz, PhD, Kaiser Permanente Research Bank, Oakland, CA, USA

The "All of Us" Research Program- Precision Medicine Initiative: 1 Million Cohort

Mine S. Cicek, PhD, Mayo Clinic, MN, USA

AMP Bioinformatics Pipeline Validation Working Group
(Sponsored by the Clinical Practices Committee)

AMP Bioinformatics Pipeline Validation Working Group: Development of Guidelines
Somak Roy, MD, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

New AMP Guidelines on Validating Next Generation Sequencing Bioinformatics Pipelines
Alexis B. Carter, MD, Children's Healthcare of Atlanta, Atlanta, GA, USA

Molecular Pathology of Pancreatic Neoplasms

Molecular Diagnostic Testing for the Detection of Early Pancreatobiliary Neoplasms
Aatur Singhi, MD, PhD, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, PA, USA

8:00am - 9:00am

SPECIAL SESSION: INFECTIOUS DISEASES

Technologist Round Table: Troubleshooting in Molecular ID Lab

Passing the Baton: Keys to Successful Implementation of Laboratory Developed Tests (LDTs) and FDA-cleared Tests
Melissa R. Johnson, BSc, ARUP Laboratories, Salt Lake City, UT, USA

Jeff Stevenson, PhD, ARUP Laboratories, Salt Lake City, UT, USA

Jeffrey Chumley, BSc, ARUP Laboratories, Salt Lake City, UT, USA

8:00am - 8:15am

Break

8:15am - 9:45am

INHERITED CONDITIONS PLENARY SESSION

Mitochondrial Disease: Diagnosis, Treatment and Prevention

Overview of Mitochondrial Disease and Nuclear Genetic Causes
Marni J. Falk, MD, Children's Hospital of Philadelphia, Philadephia, PA
University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA

Mitochondrial DNA Disease: Etiology, Diagnosis, and Prevention
Sir Doug Turnbull, MBBS, MD, PhD, Newcastle University, Newcastle, UK

9:45am - 10:45am

Coffee Break - Visit Exhibit Hall and View Posters

10:45am - 12:15pm

CONCURRENT WORKSHOPS

Whole Exome Sequencing in Clinical Practice

Development and Validation of a Whole-exome Sequencing Test for Simultaneous Detection of Point Mutations, Indels and Copy-number Alterations for Precision Cancer Care
Oliver Elemento, PhD, Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA
 
Integrated Genomic Profile Using Clinical Whole Genome and Transcriptome Sequencing to Enable Precision Oncology
Vaidehi Jobanputra, PhD, New York Genome Center, New York, NY, USA

Crowd-sourcing the Expert Curation of Germline and Somatic Variants: CiVic, ClinGen and Clinvar

Heidi L. Rehm, PhD, Harvard Medical School, Boston, MA, USA

Obi L. Griffith, PhD, Washington University School of Medicine, St. Louis, MO, USA

Molecular Detection of Resistance: Ready for Prime Time?

Bacterial Resistance:  Detection with Molecular Methods
Robert A. Bonomo, MD, Louis Stokes VA Medical Center, Cleveland, OH, USA
 
Deep Sequencing for HIV-1 Clinical Management
Maria Casadellà, PhD, IrsiCaixa AIDS Research Institute, Barcelona, Spain

Review and Implementation of New AMP Guidelines on NGS Somatic Variant Test Validation, Interpretation, and Reporting
(Sponsored by the Clinical Practices Committee)

 
Development of the AMP/CAP Validation of NGS for Somatic Variants Guideline
Lawrence J. Jennings, MD, PhD, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA
 
Somatic Variant Interpretation and Reporting
Marilyn M. Li, MD, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
 
Practical Applications of New AMP Guidelines on NGS Somatic Variant Test Validation, Interpretation, and Reporting
Marina N. Nikiforova, MD, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

What is the Legal Risk for Interpreting and Classifying Sequencing Variants in the Laboratory
(Sponsored by the Professional Relations Committee)

Panel Discussion

John D. Pfeifer, MD, PhD, Washington University School of Medicine, St. Louis, MO, USA
 
Robert Cook-Deegan, Arizona State University, Washington, DC, USA
 
Jamie McDonald, MSc, University of Utah, Salt Lake City, UT, USA
 

12:15pm - 1:30pm

General Lunch - Visit Exhibit Hall and View Posters

Networking Lunches (schedule)

1:30pm - 3:00pm

CONCURRENT SYMPOSIA

C. difficle Testing: Pros and Cons of Testing Algorithms

Diagnosis of Clostridium difficile Infections- The Benefits of Molecular Testing
Ferric C. Fang, MD, University of Washington, School of Medicine, Seattle, WA, USA

Diagnosis of Clostridium difficile Infections- Why Toxin Tests Still Matter
Christopher R. Polage, MD, MAS, University of California, Davis School of Medicine, Sacramento, CA, USA

Emerging Technology for Structural Variant Detection

Mate-Pair Sequencing in Cytogenetics
Nicole L. Hoppman, PhD, Mayo Clinic, Rochester, MN, USA

Digital Karyotyping and Complex Rearrangement Analysis with Sequencing at Single Molecule Resolution
Hanlee P. Ji, MD, Stanford University School of Medicine, Stanford, CA, USA

3:00pm - 3:15pm

Break

3:15pm - 4:45pm

PLENARY SESSION

Role of Genome Editing in Research and Therapy

Genome and Epigenome Editing with CRISPR-Cas Nucleases
J. Keith Joung, MD, PhD, Massachusetts General Hospital, Charlestown, MA, USA

Accelerating Prediction of Tumor Vulnerabilities Using Next-generation Cancer Models
Jesse S. Boehm, PhD, Broad Institute, Cambridge, MA, USA

4:45pm - 5:00pm

Closing Remarks

Daniel E. Sabath MD, PhD
Director, Red Cell Disorders, Molecular Diagnosis and General Laboratories, University of Washington
2017 Program Chair